SmartBone Bone Regeneration - Bone Graft 1gr
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SmartBone Bone Regeneration - Bone Graft 1gr
A Bone graft born from Advanced Tissue Engineering Technology
SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® are produced by combining natural mineral bone structures with bioresorbable polymers and collagen fragments. This new concept of biomaterial assembly allows the patient’s cells to grow quickly and efficiently into the bone substitute while the biopolymers degrade, providing perfect integration and osteogenesis. Moreover, thanks to this technology our graft mimics the human bone, it is mechanically strong and resistant to shaping, screws and surgical fixation maneuvers.
SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® are exactly the same products with just different brand names or different indications of use.
BOVINE BONE MATRIX
has a chemical structure and a morphology that resemble the human bone
is rigid, but not elastic, and thus too fragile (since the mineral matrix loses its biomechanical properties without proteins lost during the cleaning processes)
BIODEGRADABLE POLYMERS
Allow to have:
high loading resistance
high volumetric stability (>95%); the polymers protect the bone from early resorption
COLLAGEN FRAGMENTS
Help to:
promote blood cells adhesion and colonization
guarantee a high hydrophilicity thus enhancing the biochemical cascade of signals that promotes the osteoinductive process
Human-Like Microstructure
The microstructure of SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone®’s composite matrix strongly resembles the human bone in terms of open, interconnected and mid-sized porosity. Indeed, it mimics the characteristics of a healthy human bone: high biocompatibility, adequate open porosity, high mechanical performance, hydrophilicity.
SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® were designed to reduce the inner variability that many other bone substitutes have, due to their natural origin. IBI offers homogeneous bone substitutes with regular microstructure, porosity, density and mechanical properties.
Extremely high hydrophilicity and fast osteointegration
Thanks to its microcomposition, SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® quickly reach an av. 38%w/w blood swelling ratio, thereby sparking the chemical signaling cascade that finally induces a robust osteointegration.
High tissue integration
SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone®’s microstructure and composition favor cell colonization.
In Vitro studies
The electronic microscopy analyses of in vitro cell colonization tests evidenced the presence of wide and well-structured cell formations inside SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone®, proving confirmation to the biochemical data collected during ISO standard in vitro tests. Biological and histological investigations showed how our bone substitutes are very supportive substrates for cell adhesion and growth; Human adipose-tissue derived Mesenchymal Stem Cells showed in vitro capability to properly colonize the scaffold and, once induced, to differentiate.
In Vivo Studies
Studies were performed to assess osteointegration on a 4-month observation timeframe. Histological analysis proved confirmation of SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® integration, with natural bone formation, including cells and vessels colonizing pores within it over time.
Dental indications
SmartBone® is intended to be used for reconstruction surgeries and for bone regeneration/augmentation, in the following indications:
Easy dust free shaping with any type of surgical tool (for example: bone cutter, drill);
Resistant to heavy loads and to heavy surgical maneuvering;
Far better stability of the augmented bone graft vs the loose granules;
Bigger defects do not need autologous bone, thus reducing patient morbidity;
No resorption: the polymeric coating protects the graft during initial healing/osteointegration period;
Readily absorbs blood.
Dental indications
SmartBone® is intended to be used for reconstruction surgeries and for bone regeneration/augmentation, in the following indications:
Regeneration of periodontal bone defects;
Regeneration of extraction alveoli;
Regeneration of cavities between the alveolar wall and immediate implants;
Horizontal alveolar ridge augmentation;
Sinus lift floor elevation;
Alveolar ridge augmentation at implant sites with sufficient residual bone and a good blood supply.