Ghimas Chlosite Subgingival Antimicrobial Local Antiseptic Chlorhexidine Gel 6*0.25 ml

Chlo-Site – Controlled-Release, Chlorhexidine-Containing Bioadhesive Periodontal Gel

Chlo-Site is a long-acting, controlled-release bioadhesive gel developed for subgingival application, containing xanthan-based, dual-form chlorhexidine. It is used as an adjunctive therapy after mechanical debridement (SRP) in periodontal treatment. Thanks to its gel structure, it adheres to tissue and can remain in the pocket for up to 20 days, suppressing bacterial biofilm and preventing re-colonization.

Pharmacological Structure

Chlo-Site features a patented combination of two different chlorhexidine forms:

• Chlorhexidine Digluconate 0.5%: Provides immediate antimicrobial effect
• Chlorhexidine Dihydrochloride 1.0%: Offers long-lasting effect through controlled release

The carrier agent xanthan gum ensures that active ingredients remain in the periodontal pocket for an extended period thanks to its dense and viscoelastic structure. This mucoadhesive structure allows the material to adhere to surfaces without being rapidly washed away by oral fluids.

Mechanism of Action

• Causes microbial death by disrupting bacterial membranes and destroying intracellular contents
• Creates high local chlorhexidine concentration in the subgingival area
• Xanthan polymer slowly and continuously releases the active ingredients

Can remain effective for up to 20 days – preventing re-colonization throughout this period

Clinical Application Areas

Chlo-Site is recommended as a local treatment agent in various periodontal and peri-implant conditions:

• Gingivitis and early-stage periodontitis (Stage I–II)
• Deep periodontal pockets (≥5 mm) – adjunctive therapy in Stage III–IV cases
• Peri-implantitis and mucositis treatment
• Residual pocket management after SRP
• Supportive maintenance around dental implants
• As an alternative to non-surgical periodontal treatment

Clinical Application Method

1. Mechanical debridement (SRP) must be performed before application
2. The gel is applied directly into the periodontal or peri-implant pocket with a syringe
3. The 1 ml format can be used in multiple areas; the 0.25 ml format is ideal for local lesions
4. No rinsing for the first 2 hours; hard chewing is not recommended
5. Can be re-applied at 1–5 week intervals depending on the healing process

Clinical Data

In multicenter randomized controlled clinical studies, groups treated with Chlo-Site showed:

• Average 0.8–0.9 mm reduction in probing depth
• Significant decrease in subgingival P. gingivalis and T. forsythia levels
• Antibacterial effect continued to be observed even at 6 months
• SRP + Chlo-Site combination showed higher success than SRP alone (p<0.001)

Forms and Packaging

• 6*1 ml sterile syringes – multi-pocket applications

Advantages

• High local effect without the need for systemic antibiotics
• Accelerates healing time when applied after SRP
• The only gel format that can remain active for 20 days
• High tissue compatibility, low risk of irritation
• Can also be applied by dental hygienists

Application Protocols by Indication

Chlo-Site enables repeatable controlled applications at different stages of periodontal disease and in peri-implant conditions, at the clinician's discretion. Clinical applications are recommended as follows based on periodontal pocket depth and disease stage:

1. Mucositis and Gingivitis

• The area is cleaned and carefully dried before application
• Chlo-Site is applied directly to the lesion area
• If symptoms persist, application is repeated at the next session
• The clinician determines the follow-up interval based on PSR (Periodontal Screening and Recording Index) values

2. Stage I Periodontitis or Pockets Shallower Than 3 mm

• Chlo-Site is applied after supragingival plaque removal
• Re-application is planned for a minimum of 2 sessions for the patient
• Number of applications can be increased at the clinician's discretion

3. Stage II Periodontitis or 4 mm Pockets

• Subgingival plaque is removed (SRP is performed)
• At least 3 repeat sessions are planned after the first application
• Additional sessions may be performed based on observation and healing

4. Stage III Periodontitis or Pockets Over 5 mm

• Chlo-Site is applied into the pocket after SRP
• Minimum 4 applications should be planned; decision should be made with clinical follow-up

5. Stage IV Periodontitis or Pockets Over 6 mm

• Chlo-Site is applied after intensive subgingival debridement (SRP)
• At least 5 applications are recommended; continuity depends on disease progression

6. Preventive Use in Stable Periodontal Patients

• In patients with reduced periodontium, especially at borderline measurements
• Can be applied after supragingival cleaning at annual check-up sessions
• Helps maintain periodontal status

7. Prosthetic Implantology

• Can be applied in all spaces within the implant that will be closed with a screw
• Can be used both at fixture level and on prosthetic intermediate parts such as MUA (Multi Unit Abutment)

8. Pre-Periodontal Surgery Preparation

• Before major surgeries, to obtain healthier soft tissue
• Applied to the sulcus or pocket after supragingival or juxtagingival cleaning
• Application aims to reduce microbial load in the surgical area and improve healing quality